Disease
Diseases 
are negative conditions functionally similar to Quirks, that are sometimes contracted by heroes from enemy attacks, curios, traps, and occasionally at the end of a dungeon.
Most diseases are only harmful, giving significant penalties to any of a hero's stats, particularly Resists, MAX HP, and ACC. However, some diseases also carry a positive buff, namely Rabies, which grants +15% DMG but -10 ACC; The Fits, which grants +3 SPD but -5 ACC and -5% CRIT; and Grey Rot
, which grants +20% Max HP but -10 ACC and -10% DMG.
Diseases last until removed. They can be cured in the Sanitarium for some gold (where there is a chance of multiple diseases being cured at once depending on upgrade level) or by using the camping skills from the Grave Robber or the Plague Doctor (which will cure all the diseases on the targeted hero). Additionally, the Flagellant
can cure one of his own diseases with one of his camping skills.
The chance of contracting a disease at the end of a dungeon is 32% − (33% × Disease Resist), with a minimum of at least 5%. You can only get diseases at the end of a dungeon if the hero's Resolve Level is at least 2. A hero can have at most 3 diseases at once; if they acquire a new one, it will replace an old disease picked at random.
The maximum disease resistance is 95%.
List of Diseases
| Disease | Effect |
|---|---|
| Bad Humors | -20% MAX HP |
| Black Plague | -75% Blight Resist -75% Disease Resist -10% MAX HP -5 SPD |
| Bulimic | -20% Healing Skills while Camping |
| Creeping Cough | -20% DMG |
| Ennui | -25% Virtue Chance |
| Grey Rot
|
+20% MAX HP -10 ACC -10% DMG |
| Hemophilia | -50% Bleed Resist |
| Hysterical Blindness | -20 ACC if Stress above 70 |
| Lethargy | -4 SPD |
| Rabies | +15% DMG -10 ACC |
| Scurvy | -40% Bleed Resist -40% Move Resist |
| Sky Taint
|
+20% Stress -20% Bleed Resist -20% Blight Resist |
| Spasm of the Entrails | -20% Healing Skills while Camping |
| Spotted Fever | -50% Blight Resist |
| Syphilis | -5 ACC -10% DMG -10% MAX HP |
| Tapeworm | +100% Food Consumed 60% chance to interact with "Food" curios (steals loot) |
| Tetanus | -5 ACC -5% CRIT |
| The Ague | -10% DMG -3 SPD -10% MAX HP |
| The Fits | +3 SPD -5 ACC -5% CRIT |
| The Red Plague | -75% Bleed Resist -10% MAX HP -5% CRIT |
| The Runs | -20 DODGE -10% MAX HP |
| The Worries | +30% Stress |
| Vertigo | -50% Move Resist |
| Vampiric Spirits | -50% Debuff Resist |
| Wasting Sickness | -50% Disease Resist |
The Crimson Curse
The Crimson Court DLC adds a new unique disease known as the Crimson Curse. Usually it can only be contracted by fighting Bloodsucker enemies, and it has several unique properties, such as conferring particular buffs and debuffs that change over time. Any character with the Curse cannot have any other diseases, and any disease they had will be removed upon acquiring the Curse.
Disease Resist
Heroes' resistance to diseases is one of two resistances that isn't increased by Resolve Level, the other being Death Blow resistance.
The list of heroes by their disease resistance, from highest to lowest:
| Disease Resist | |||||
|---|---|---|---|---|---|
|
|
|
|
|
|
| Plague Doctor | Occultist | Flagellant
|
Arbalest | Musketeer | Crusader |
| 50% | 40% | 40% | 30% | 30% | 30% |
|
|
|
|
|
|
| Grave Robber | Hellion | Highwayman | Houndmaster | Man-at-Arms | Vestal |
| 30% | 30% | 30% | 30% | 30% | 30% |
|
|
|
|
|
|
Shieldbreaker
|
Abomination | Antiquarian | Bounty Hunter | Jester | Leper |
| 30% | 20% | 20% | 20% | 20% | 20% |
Attacks that can cause Diseases
| Monster | Attack(s) | Disease | Chance | |
|---|---|---|---|---|
| Ghoul | 
|
Howl | The Worries | 5% |
| Maggot | 
|
Grave Nibble | Any | 15% |
| Swine Wretch | 
|
Vomit | Any | 33% |
| Carrion Eater | 
|
Munch | Any | 7% (Veteran) 9% (Champion) |
| Fungal Artillery | 
|
Rain of Blight | Any | 15% |
| Rabid Gnasher | 
|
Rabid Rush | Rabies | 10% |
| Crone | 
|
Fetid Censer | Any | 7% (Veteran) 9% (Champion) |
| Sea Maggot | 
|
Brine | Any | 8% |
| Deep Stinger | 
|
Salty Gouge Shocker |
Any Any |
6% 6% |
| The Shrieker | 
|
Regurgitate | Any | 15% |
| Thing from the Stars 
|
|
Phase Gnaw | Sky Taint | 20% (Apprentice) 22% (Veteran) 25% (Champion) |
Curios that can cause Diseases
| Name | Curio | Disease | Chance |
|---|---|---|---|
| Decorative Urn | 
|
Creeping Cough Any |
7.4% 3.7% |
| Iron Maiden | 
|
Tetanus Any |
13.3% 6.7% |
| Dinner Cart | 
|
Any | 25% |
| Makeshift Dining
Table |
|
Any | 25% |
| Pile of Bones | 
|
Any | 25% |
| Beast Carcass | 
|
Rabies | 28.6% |
| Shallow Grave | 
|
Any | 50% |
| Bas-Relief | 
|
Any | 8.3% |
| Brackish Tide Pool | 
|
Any | 25% |
| Fish Carcass | 
|
The Red Plague | 16.7% |
| Bloodflowers |
|
Tetanus Any |
5.1% 2.5% |
| Damned Fountain | 
|
Crimson Curse | 20% |
| Forgotten Delicacies | 
|
Crimson Curse Any |
13.3% 6.7% |
| Hooded Shrew | 
|
Any | 7.6% |
| Wizened Shrew | 
|
Any | 7.6% |
| Pile of Strange Bones | 
|
Crimson Curse | 10% |
| Wine Crate | 
|
Crimson Curse | 16.7% |
Trivia
- The Carrion Eater, Thing From The Stars, and Crone have the only effects that increase Disease chance at higher levels.
- Spasm of the Entrails was formerly known as Griping in the Guts.