Disease (Darkest Dungeon II)

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The Leper contracting The Worries after being attacked by a Lost Soul.
We can suffer no sickness on this pilgrimage.
~ The Academic.

Disease Diseases are negative conditions that heroes can contract during an expedition. Diseases are contracted mainly from enemies but can be contracted from other sources such as Academic's Studies and Inn items. The negative quirk hypochondriac gives the affected hero a 5% chance to contract a random disease when hitting an enemy.

Diseases are harmful and their purpose is to incapacitate the hero and reduce them and their team's effectiveness. The player must learn to deal with the disadvantages and, if possible, get rid of the disease as soon as possible. However, diseases can occasionally have positive connotations for the player should they find trinkets that synergise with disease.

Dealing with diseases

Diseases are mainly treated in the Field Hospital, for the cost of 12 relics the player can get rid of any disease. They can also be treated with the inn items "Leeches" and "Experimental Remedy". The "Peculiar Pods" trinket also has a chance to cure a disease when hit by enemies. And if the player is confident, they can go to the Chirurgeon's Table to treat any diseases by facing a challenging fight instead of paying relics or using items. Additionaly, one of the items that can be obtained from a Creature Den can remove diseases from the entire party once they arrive at the inn, along with a massive 2 mastery points. This method isnt as reliable however, as it requires the second fight to include either Carrion Eaters or Carrion Devourers and not obtain the other deliverable that can be obtained from those enemies (without considering that other enemies can also appear in the second fight, lowering the chances even further).

Each hero can only contract one disease at a time. If a hero with one disease contracts another, it will simply replace the disease the hero already had.

List of Diseases

Disease Effect
Algal Bloom

Turn Start: Token barnacle.png (5%) or 2 DMG (5%)

Bad Humours

-15% Max HP

Bloody Flux -10% Max HP

-25% Healing Received from Skills

Botulism

-15% Max HP Round Start: Blind or Dd2 token daze.png (5%)

Brittle Bones

Combat Start: -5% Max HP (stacks infinitely)

Cholera

-50% Healing Received from Skills

Round Start: Dd2 token daze.png
Creeping Cough

-20% DMG

Diphtheria Round Start: Stun (5%)

When Stress Damaged: 1 DMG or 2 DMG

Dysentery

On Entering Region: -20% Max HP (stacks infinitely)

Fainting Spells

-100% Stun RES

Round Start: Stun (5%)
Hemic Rot

Round Start: Weak (15%)

Hemorrhagic Fever

-20% Bleed RES

When Moving: Bleed (5%)
Leprosy

-4 Speed

Round Start: Blind (10%)
Periodic Paralysis

-3 Speed

Round Start: Stun (5%) or Immobilize (15%)
Rabies

-5% Max HP

Round Start: Blind (7%) or Strength (3%)
Smallpox

-20% Max Icon HP dd2.png

Round Start: MoveBack 1 (5%), MoveBack 2 (5%), MoveForward 1 (5%) or MoveForward 2 (5%)
Round Start: Daze (15%)
Syphilis

-25% Max HP

Combat Start: Weak (15%), Vulnerable (15%) or Blind (7%)
Tarantism

Turn Start: MoveForward 1 (10%),MoveBack 1 (10%) or Dodge (5%)

The Goops

Turn Start: Slimed (5%)

The Oozes

Turn Start: Blight2 (15%, Ignores resistance)

The Runs

Combat Start: Weakx2 (50%)

The Worries

-50% Stress RES

Typhoid

Combat Start: -1% Max HP (stacks infinitely)

Combat Start: If Flame ≥ 50: Blindx2
Wasting Disease

-20% Max HP

-100% Traveling Heal

Table of Disease Resistances

HeroBaseUpgraded
DiseaseDisease
Portraits-abom.png Abomination40%40%
Portraits-color-bountyhunter .png Bounty Hunter40%40%
Portraits-color-bountyhunter .png Bounty Hunter (Kingdoms)30%30%
Portraits-color-crusader.png Crusader30%30%
Portraits-color-duelist.png Duelist30%30%
Portraits-color-flagellant.png Flagellant75%75%
Portraits-graverobber.png Grave Robber30%30%
Portraits-hellion.png Hellion20%30%
Portraits-highwayman.png Highwayman30%40%
Portraits-jester.png Jester30%30%
Portraits-leper.png Leper30%30%
Portraits-manatarms.png Man-at-Arms30%30%
Portraits-occultist.png Occultist30%40%
Portraits-plaguedoctor.png Plague Doctor40%50%
Portraits-runaway.png Runaway30%30%
Portraits-color-vestal.png Vestal20%20%

See Also