Disease (Darkest Dungeon II)

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The Leper contracting The Worries after being attacked by a Lost Soul.
We can suffer no sickness on this pilgrimage.
~ The Academic.

Disease dd2.png Diseases are negative conditions that heroes can contract during an expedition. Diseases are contracted mainly from enemies but can be contracted from other sources such as Academic's Studies and Inn items. The negative quirk hypochondriac gives the affected hero a 5% chance to contract a random disease when hitting an enemy.

Diseases are harmful and their purpose is to incapacitate the hero and reduce them and their team's effectiveness. The player must learn to deal with the disadvantages and, if possible, get rid of the disease as soon as possible. However, diseases can occasionally have positive connotations for the player should they find trinkets that synergise with disease.

Dealing with diseases

Diseases are mainly treated in the Field Hospital, for the cost of 12 relics the player can get rid of any disease. They can also be treated with the inn items "Leeches" and "Experimental Remedy". The "Peculiar Pods" trinket also has a chance to cure a disease when attacking enemies.

Each hero can only contract one disease at a time. If a hero with one disease contracts another, it will simply replace the disease the hero already had.

List of Diseases

Disease Effect
Algal Bloom+
  • Turn Start: Token barnacle.png (5%) or 2 DMG (5%)
Bad Humours
  • -15% Max Icon HP dd2.png
Bloody Flux
  • -10% Max Icon HP dd2.png
  • -25% Healing received from Skills.
Brittle Bones+
  • Combat Start: -5% Max Icon HP dd2.png
Botulism+
  • -15% Max HP
  • Round Start: Blind or Daze (5%)
Cholera
  • -50% Healing recieved from Skills
  • Round start: Dd2 token daze.png
Creeping Cough+
  • -20% Damage dealt
Diptheria+
  • When Stress Damaged: 1 DMG or 2 DMG
  • Round start: Dd2 token stun.png (5%)
Dysentery
  • On Entering a region: -20% Max Icon HP dd2.png
Fainting Spells
  • -100% Stun dd2.png Resistance.
  • Round start: Dd2 token stun.png (5%)
Hemic Rot
  • Round start: Dd2 token weak.png(15%)
Hemorrhagic Fever
  • -20% Bleed dd2.pngResistance.
  • When Moving: 1 Bleed dd2.png (5%)
Leprosy+
  • -4 Icon speed.png
  • Round start: Dd2 token blind.png (10%)
Periodic Paralysis+
  • -3 Icon speed.png
  • Round start: Dd2 token stun.png (5%) or Dd2 token immobilize.png (15%)
Rabies
  • -5% Max Icon HP dd2.png
  • Round start: Dd2 token blind.png (7%) or Dd2 token strength 2.png (3%)
Smallpox+
  • -20% max Icon HP dd2.png
  • Round start: Back 1 (5%), Back 2 (5%), Forward 1 (5%) or Forward 2 (5%)
Syphilis
  • -25% Max Icon HP dd2.png
  • Combat start: Dd2 token weak.png (15%), Dd2 token vulnerable.png(15%) or Dd2 token blind.png(7%)
Tarantism
  • Turn start: Forward 1 (10%), Back 1 (10%) or Dd2 token dodge.png(5%)
The Oozes+
  • Turn start: 3 Blight dd2.png (15%, Ignores resistance)
The Worries
  • -50% Dd2 token stress.png Resistance.
Typhoid
  • Combat Start: -1% Max Icon HP dd2.png
  • Combat Start: If torch > 50: 2 Dd2 token blind.png
Wasting Disease
  • -20% Max Icon HP dd2.png
  • -100% Road healing

Table of Disease Resistances

HeroBaseUpgraded
DiseaseDisease
Portraits-story-bountyhunter.png Bounty Hunter40%40%
Portraits-color-crusader.png Crusader30%30%
Portraits-color-duelist.png Duelist30%30%
Portraits-color-flagellant.png Flagellant75%75%
Portraits-graverobber.png Grave Robber30%30%
Portraits-hellion.png Hellion20%30%
Portraits-highwayman.png Highwayman30%40%
Portraits-jester.png Jester30%30%
Portraits-leper.png Leper30%30%
Portraits-manatarms.png Man-at-Arms30%30%
Portraits-occultist.png Occultist30%40%
Portraits-plaguedoctor.png Plague Doctor40%50%
Portraits-runaway.png Runaway30%30%
Portraits-color-vestal.png Vestal20%20%

See Also